Marvel: X-Men

Although this was not initially the case, Professor X has come to be compared to civil rights movement leader Martin Luther King Jr. and Magneto to the more militant Malcolm X.(Magneto, in the first film, quotes Malcolm X with the line "By any means necessary.") X-Men comic books have often portrayed mutants as victims of mob violence, evoking images of the lynching of African Americans in the age before the civil rights movement.[114] Sentinels and anti-mutant hate groups such as Friends of Humanity, Humanity's Last Stand, the Church of Humanity, and Stryker's Purifiers are thought to often represent oppressive forces like the Ku Klux Klan giving a form to denial of civil rights and amendments.

Some commentators have noted the similarities between the struggles of mutants and the LGBT community, noting the onset of special powers around puberty and the parallels between being closeted and the mutants' concealment of their powers. In the comics series, gay and bisexual characters include Anole, Bling!, Destiny, Karma, Mystique, Psylocke, Courier, Northstar (whose marriage was depicted in the comics in 2012), Graymalkin, Rictor, Shatterstar, Shade, the Ultimate version of Colossus and later Iceman after revealing that he is a mutant; the comics version of the character was then revealed to be gay in 2015. Transgender issues also come up with shapechangers like Mystique, Copycat, and Courier who can change gender at will. It has been said that the comic books and the X-Men animated series delved into the AIDS epidemic with a long-running plot line about the Legacy Virus, a seemingly incurable disease thought at first to attack only mutants (similar to the AIDS virus which at first was spread through the gay community).

Explicitly referenced in recent decades is the comparison between antimutant sentiment and antisemitism. Magneto, a Holocaust survivor, sees the situation of mutants as similar to those of Jews in Nazi Germany. At one point he even utters the words "never again" in a 1992 episode of the X-Men animated series. The mutant slave labor camps on the island of Genosha, in which numbers were burned into mutant's foreheads, show much in common with Nazi concentration camps, as do the internment camps of the classic "Days of Future Past" storyline. In the third X-Men film, when asked by Callisto: "If you're so proud of being a mutant, then where's your mark?" Magneto shows his concentration camp tattoo, while mentioning that he will never let another needle touch his skin. In the prequel film X-Men: First Class, a fourteen-year-old Magneto suffers Nazi human experimentation during his time in the camps and witnesses his mother's death by gunshot.

Religion is an integral part of several X-Men storylines. It is presented as both a positive and negative force, sometimes in the same story. The comics explore religious fundamentalism through the person of William Stryker and his Purifiers, an antimutant group that emerged in the 1982 graphic novel God Loves, Man Kills. The Purifiers believe that mutants are not human beings but children of the devil, and have attempted to exterminate them several times, most recently in the "Childhood's End" storyline. By contrast, religion is also central to the lives of several X-Men, such as Nightcrawler, a devout Catholic, and Dust, a devout Sunni Muslim who wears an Islamic niqāb.

Occasionally, undercurrents of the real-life "Red Scare" are present or the events of the Red Scare in history are alluded to. Senator Robert Kelly's proposal of a Mutant Registration Act is similar to the efforts of United States Congress to try to ban communism in the United States. In the 2000 X-Men film, Kelly exclaims, "We must know who these mutants are and what they can do," even brandishing a "list" of known mutants (a reference to Senator Joseph McCarthy's list of Communist Party USA members who were working in the government).